Recombinant γY278H Fibrinogen Showed Normal Secretion from CHO Cells, but a Corresponding Heterozygous Patient Showed Hypofibrinogenemia

We identified a novel heterozygous hypofibrinogenemia, γY278H (Hiroshima). To demonstrate the cause of reduced plasma fibrinogen levels (functional level: 1.12 g/L and antigenic level: 1.16 g/L), we established γY278H fibrinogen-producing Chinese hamster ovary (CHO) cells. An enzyme-linked immunosor...

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Detalles Bibliográficos
Autores principales: Kamijo, Tomu, Kaido, Takahiro, Yoda, Masahiro, Arai, Shinpei, Yamauchi, Kazuyoshi, Okumura, Nobuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156302/
https://www.ncbi.nlm.nih.gov/pubmed/34069309
http://dx.doi.org/10.3390/ijms22105218

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156302/
https://www.ncbi.nlm.nih.gov/pubmed/34069309
http://dx.doi.org/10.3390/ijms22105218

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