Gene-Directed Enzyme Prodrug Therapy by Dendrimer-Like Mesoporous Silica Nanoparticles against Tumor Cells

We report herein a gene-directed enzyme prodrug therapy (GDEPT) system using gated mesoporous silica nanoparticles (MSNs) in an attempt to combine the reduction of side effects characteristic of GDEPT with improved pharmacokinetics promoted by gated MSNs. The system consists of the transfection of c...

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Detalles Bibliográficos
Autores principales: Candela-Noguera, Vicente, Vivo-Llorca, Gema, Díaz de Greñu, Borja, Alfonso, María, Aznar, Elena, Orzáez, Mar, Marcos, María Dolores, Sancenón, Félix, Martínez-Máñez, Ramón
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156333/
https://www.ncbi.nlm.nih.gov/pubmed/34069171
http://dx.doi.org/10.3390/nano11051298

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156333/
https://www.ncbi.nlm.nih.gov/pubmed/34069171
http://dx.doi.org/10.3390/nano11051298

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