Streptozotocin-Induced Hyperglycemia Affects the Pharmacokinetics of Koumine and its Anti-Allodynic Action in a Rat Model of Diabetic Neuropathic Pain

Koumine (KM), the most abundant alkaloid in Gelsemium elegans, has anti-neuropathic, anti-inflammatory, and analgesic activities; thus, it has the potential to be developed as a broad-spectrum analgesic drug. However, factors determining the relationship between analgesic efficacy and the correspond...

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Detalles Bibliográficos
Autores principales: Ye, Li-Xiang, Huang, Hui-Hui, Zhang, Shui-Hua, Lu, Jing-Shan, Cao, Da-Xuan, Wu, Dan-Dan, Chi, Pei-Wang, Hong, Long-Hui, Wu, Min-Xia, Xu, Ying, Yu, Chang-Xi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156416/
https://www.ncbi.nlm.nih.gov/pubmed/34054521
http://dx.doi.org/10.3389/fphar.2021.640318

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156416/
https://www.ncbi.nlm.nih.gov/pubmed/34054521
http://dx.doi.org/10.3389/fphar.2021.640318

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