Cargando…

Streptozotocin-Induced Hyperglycemia Affects the Pharmacokinetics of Koumine and its Anti-Allodynic Action in a Rat Model of Diabetic Neuropathic Pain

Koumine (KM), the most abundant alkaloid in Gelsemium elegans, has anti-neuropathic, anti-inflammatory, and analgesic activities; thus, it has the potential to be developed as a broad-spectrum analgesic drug. However, factors determining the relationship between analgesic efficacy and the correspond...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ye, Li-Xiang, Huang, Hui-Hui, Zhang, Shui-Hua, Lu, Jing-Shan, Cao, Da-Xuan, Wu, Dan-Dan, Chi, Pei-Wang, Hong, Long-Hui, Wu, Min-Xia, Xu, Ying, Yu, Chang-Xi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156416/ https://www.ncbi.nlm.nih.gov/pubmed/34054521 http://dx.doi.org/10.3389/fphar.2021.640318

Ejemplares similares

Orally Administered Koumine Persists Longer in the Plasma of Aged Rats Than That of Adult Rats as Assessed by Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry
por: Ye, Li-Xiang, et al.
Publicado: (2020)

Koumine Decreases Astrocyte-Mediated Neuroinflammation and Enhances Autophagy, Contributing to Neuropathic Pain From Chronic Constriction Injury in Rats
por: Jin, Gui-lin, et al.
Publicado: (2018)

Identification of Koumine as a Translocator Protein 18 kDa Positive Allosteric Modulator for the Treatment of Inflammatory and Neuropathic Pain
por: Xiong, Bojun, et al.
Publicado: (2021)

Anti-Allodynic Effects of Levodopa in Neuropathic Rats
por: Park, Hue Jung, et al.
Publicado: (2013)

Koumine Attenuates Neuroglia Activation and Inflammatory Response to Neuropathic Pain
por: Jin, Gui-Lin, et al.
Publicado: (2018)

Sulforaphane Inhibited the Nociceptive Responses, Anxiety- and Depressive-Like Behaviors Associated With Neuropathic Pain and Improved the Anti-allodynic Effects of Morphine in Mice
por: Ferreira-Chamorro, Pablo, et al.
Publicado: (2018)

Investigation of the Possible Allostery of Koumine Extracted From Gelsemium elegans Benth. And Analgesic Mechanism Associated With Neurosteroids
por: Xiong, Bojun, et al.
Publicado: (2021)

Chemogenetic Regulation of CX3CR1-Expressing Microglia Using Gi-DREADD Exerts Sex-Dependent Anti-Allodynic Effects in Mouse Models of Neuropathic Pain
por: Saika, Fumihiro, et al.
Publicado: (2020)

Downregulation of Candidate Gene Expression and Neuroprotection by Piperine in Streptozotocin-Induced Hyperglycemia and Memory Impairment in Rats
por: Kumar, Suresh, et al.
Publicado: (2021)

Cilostazol Ameliorates Peripheral Neuropathic Pain in Streptozotocin-Induced Type I Diabetic Rats
por: Cheng, Kuang-I., et al.
Publicado: (2022)

Investigation of Natural Compounds for Therapeutic Potential in Streptozotocin-induced Diabetic Neuroinflammation and Neuropathic Pain
por: Faheem, Muhammad, et al.
Publicado: (2022)

Koumine enhances spinal cord 3α-hydroxysteroid oxidoreductase expression and activity in a rat model of neuropathic pain
por: Qiu, Hong-Qiang, et al.
Publicado: (2015)

Anti-Allodynic Effects of Polydeoxyribonucleotide in an Animal Model of Neuropathic Pain and Complex Regional Pain Syndrome
por: Lee, Sung Hyun, et al.
Publicado: (2020)

Koumine Suppresses IL-1β Secretion and Attenuates Inflammation Associated With Blocking ROS/NF-κB/NLRP3 Axis in Macrophages
por: Luo, Yufei, et al.
Publicado: (2021)

Anti-allodynic Effect of Mangiferin in Rats With Chronic Post-ischemia Pain: A Model of Complex Regional Pain Syndrome Type I
por: Garrido-Suárez, Bárbara B., et al.
Publicado: (2018)

Anti-allodynic Efficacy of NMDA Antagonist Peptide and Noradrenaline Alone and in Combination in Rodent Neuropathic Pain Model
por: Nasirinezhad, Farinaz, et al.
Publicado: (2015)

A 4/8 Subtype α-Conotoxin Vt1.27 Inhibits N-Type Calcium Channels With Potent Anti-Allodynic Effect
por: Wang, Shuo, et al.
Publicado: (2022)

Molecular basis for the dosing time-dependency of anti-allodynic effects of gabapentin in a mouse model of neuropathic pain
por: Kusunose, Naoki, et al.
Publicado: (2010)

Involvement of spinal muscarinic and serotonergic receptors in the anti-allodynic effect of electroacupuncture in rats with oxaliplatin-induced neuropathic pain
por: Lee, Ji Hwan, et al.
Publicado: (2016)

Peripheral Delta Opioid Receptors Mediate Formoterol Anti-allodynic Effect in a Mouse Model of Neuropathic Pain
por: Ceredig, Rhian Alice, et al.
Publicado: (2020)

Medial septum glutamatergic neurons modulate nociception in chronic neuropathic pain via projections to lateral hypothalamus
por: Fan, Bing-Qian, et al.
Publicado: (2023)

Synergistic anti-allodynic effect between intraperitoneal thalidomide and morphine on rat spinal nerve ligation-induced neuropathic pain
por: Lee, Hyung Gon, et al.
Publicado: (2013)

Role of Keap1-Nrf2 Signaling in Anhedonia Symptoms in a Rat Model of Chronic Neuropathic Pain: Improvement With Sulforaphane
por: Li, Shan, et al.
Publicado: (2018)

Population pharmacokinetics of intravenous colistin sulfate and dosage optimization in critically ill patients
por: Xie, Yue-liang, et al.
Publicado: (2022)

Astragaloside IV improves the pharmacokinetics of febuxostat in rats with hyperuricemic nephropathy by regulating urea metabolism in gut microbiota
por: Zhao, Zhen Xiong, et al.
Publicado: (2022)

Anti-allodynic effect induced by curcumin in neuropathic rat is mediated through the NO-cyclic-GMP-ATP sensitive K(+) channels pathway
por: Pastrana-Quintos, Tracy, et al.
Publicado: (2020)

Immunoregulatory Effect of Koumine on Nonalcoholic Fatty Liver Disease Rats
por: Yue, Rongcai, et al.
Publicado: (2019)

Toxic Effects of Koumine on the Early-Life Development Stage of Zebrafish
por: Wang, Dongjie, et al.
Publicado: (2023)

Moderate Hyperglycemia-Preventive Effect and Mechanism of Action of Periplaneta americana Oligosaccharides in Streptozotocin-Induced Diabetic Mice
por: Lu, Kaimin, et al.
Publicado: (2022)

Anti-allodynic and Anti-hyperalgesic effects of an ethanolic extract and xylopic acid from the fruits of Xylopia aethiopica in murine models of neuropathic pain
por: Ameyaw, Elvis O., et al.
Publicado: (2014)

The impact of sofosbuvir/velpatasvir/voxilaprevir treatment on serum hyperglycemia in hepatitis C virus infections: a systematic review and meta-analysis
por: Hung, Hsuan-Yu, et al.
Publicado: (2023)

Processing and Polyherbal Formulation of Tetradium ruticarpum (A. Juss.) Hartley: Phytochemistry, Pharmacokinetics, and Toxicity
por: Shan, Qi-yuan, et al.
Publicado: (2020)

Induction of oxidative stress, apoptosis and DNA damage by koumine in Tetrahymena thermophila
por: Ye, Qiao, et al.
Publicado: (2019)

Study of the Mechanism of Action of Guanxin Shutong Capsules in the Treatment of Coronary Heart Disease Based on Metabolomics
por: Wang, Dan, et al.
Publicado: (2021)

Analgesic Action of Catechin on Chronic Constriction Injury–Induced Neuropathic Pain in Sprague–Dawley Rats
por: Foudah, Ahmed I., et al.
Publicado: (2022)

Analgesic effects and pharmacologic mechanisms of the Gelsemium alkaloid koumine on a rat model of postoperative pain
por: Xiong, Bo-Jun, et al.
Publicado: (2017)

Long-Term Anti-Allodynic Effect of Immediate Pulsed Radiofrequency Modulation through Down-Regulation of Insulin-Like Growth Factor 2 in a Neuropathic Pain Model
por: Yeh, Chun-Chang, et al.
Publicado: (2015)

Downregulation of nuclear STAT2 protein in the spinal dorsal horn is involved in neuropathic pain following chronic constriction injury of the rat sciatic nerve
por: Huang, Zhifeng, et al.
Publicado: (2023)

Pharmacokinetics of immediate and sustained-release formulations of paroxetine: Population pharmacokinetic approach to guide paroxetine personalized therapy in chinese psychotic patients
por: Li, Xiao-lin, et al.
Publicado: (2022)

Hepatic immunophenotyping for streptozotocin-induced hyperglycemia in mice
por: Lee, Young-Sun, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_tpj66jgcm8e5rlj7ubada2o8dq