Informing Pharmacokinetic Models With Physiological Data: Oral Population Modeling of L-Serine in Humans

To determine how to set optimal oral L-serine (serine) dose levels for a clinical trial, existing literature was surveyed. Data sufficient to set the dose was inadequate, and so an (n = 10) phase I-A calibration trial was performed, administering serine with and without other oral agents. We analyze...

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Detalles Bibliográficos
Autores principales: Bosley, J. R., Björnson, Elias, Zhang, Cheng, Turkez, Hasan, Nielsen, Jens, Uhlen, Mathias, Borén, Jan, Mardinoglu, Adil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156419/
https://www.ncbi.nlm.nih.gov/pubmed/34054524
http://dx.doi.org/10.3389/fphar.2021.643179

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156419/
https://www.ncbi.nlm.nih.gov/pubmed/34054524
http://dx.doi.org/10.3389/fphar.2021.643179

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