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Informing Pharmacokinetic Models With Physiological Data: Oral Population Modeling of L-Serine in Humans
To determine how to set optimal oral L-serine (serine) dose levels for a clinical trial, existing literature was surveyed. Data sufficient to set the dose was inadequate, and so an (n = 10) phase I-A calibration trial was performed, administering serine with and without other oral agents. We analyze...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156419/ https://www.ncbi.nlm.nih.gov/pubmed/34054524 http://dx.doi.org/10.3389/fphar.2021.643179 |