Disruption of YY1-EZH2 Interaction Using Synthetic Peptides Inhibits Breast Cancer Development

SIMPLE SUMMARY: Both Yin Yang 1 (YY1) and enhancer of zeste homolog 2 (EZH2) are oncogenes with overexpressed statuses in cancers. As a transcription factor, YY1 recruits EZH2 through its oncoprotein binding (OPB) domain to repress gene expression. In this study, we identified the interaction domain...

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Detalles Bibliográficos
Autores principales: Yi, Cheng, Li, Guangyue, Wang, Wenmeng, Sun, Yixuan, Zhang, Yueling, Zhong, Chen, Stovall, Daniel B., Li, Dangdang, Shi, Jinming, Sui, Guangchao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156467/
https://www.ncbi.nlm.nih.gov/pubmed/34065631
http://dx.doi.org/10.3390/cancers13102402

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156467/
https://www.ncbi.nlm.nih.gov/pubmed/34065631
http://dx.doi.org/10.3390/cancers13102402

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