Cargando…
Disruption of YY1-EZH2 Interaction Using Synthetic Peptides Inhibits Breast Cancer Development
SIMPLE SUMMARY: Both Yin Yang 1 (YY1) and enhancer of zeste homolog 2 (EZH2) are oncogenes with overexpressed statuses in cancers. As a transcription factor, YY1 recruits EZH2 through its oncoprotein binding (OPB) domain to repress gene expression. In this study, we identified the interaction domain...
Autores principales: | Yi, Cheng, Li, Guangyue, Wang, Wenmeng, Sun, Yixuan, Zhang, Yueling, Zhong, Chen, Stovall, Daniel B., Li, Dangdang, Shi, Jinming, Sui, Guangchao |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156467/ https://www.ncbi.nlm.nih.gov/pubmed/34065631 http://dx.doi.org/10.3390/cancers13102402 |
Ejemplares similares
-
A histidine cluster determines YY1-compartmentalized coactivators and chromatin elements in phase-separated enhancer clusters
por: Wang, Wenmeng, et al.
Publicado: (2022) -
YY1 Oligomerization Is Regulated by Its OPB Domain and Competes with Its Regulation of Oncoproteins
por: Qiao, Shiyao, et al.
Publicado: (2022) -
Advances of Zinc Signaling Studies in Prostate Cancer
por: Li, Dangdang, et al.
Publicado: (2020) -
Integrative genomic analyses of promoter G-quadruplexes reveal their selective constraint and association with gene activation
por: Li, Guangyue, et al.
Publicado: (2023) -
Phase-Separated Subcellular Compartmentation and Related Human Diseases
por: Zhang, Lin, et al.
Publicado: (2022)