Prediction of sgRNA Off-Target Activity in CRISPR/Cas9 Gene Editing Using Graph Convolution Network

CRISPR/Cas9 is a powerful genome-editing technology that has been widely applied in targeted gene repair and gene expression regulation. One of the main challenges for the CRISPR/Cas9 system is the occurrence of unexpected cleavage at some sites (off-targets) and predicting them is necessary due to...

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Detalles Bibliográficos
Autores principales: Vinodkumar, Prasoon Kumar, Ozcinar, Cagri, Anbarjafari, Gholamreza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156774/
https://www.ncbi.nlm.nih.gov/pubmed/34069050
http://dx.doi.org/10.3390/e23050608

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156774/
https://www.ncbi.nlm.nih.gov/pubmed/34069050
http://dx.doi.org/10.3390/e23050608

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