NO(●) Represses the Oxygenation of Arachidonoyl PE by 15LOX/PEBP1: Mechanism and Role in Ferroptosis

We recently discovered an anti-ferroptotic mechanism inherent to M1 macrophages whereby high levels of NO(●) suppressed ferroptosis via inhibition of hydroperoxy-eicosatetraenoyl-phosphatidylethanolamine (HpETE-PE) production by 15-lipoxygenase (15LOX) complexed with PE-binding protein 1 (PEBP1). Ho...

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Detalles Bibliográficos
Autores principales: Mikulska-Ruminska, Karolina, Anthonymuthu, Tamil S., Levkina, Anastasia, Shrivastava, Indira H., Kapralov, Alexandr A., Bayır, Hülya, Kagan, Valerian E., Bahar, Ivet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156958/
https://www.ncbi.nlm.nih.gov/pubmed/34067535
http://dx.doi.org/10.3390/ijms22105253

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156958/
https://www.ncbi.nlm.nih.gov/pubmed/34067535
http://dx.doi.org/10.3390/ijms22105253

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