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NO(●) Represses the Oxygenation of Arachidonoyl PE by 15LOX/PEBP1: Mechanism and Role in Ferroptosis

We recently discovered an anti-ferroptotic mechanism inherent to M1 macrophages whereby high levels of NO(●) suppressed ferroptosis via inhibition of hydroperoxy-eicosatetraenoyl-phosphatidylethanolamine (HpETE-PE) production by 15-lipoxygenase (15LOX) complexed with PE-binding protein 1 (PEBP1). Ho...

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Detalles Bibliográficos
Autores principales:	Mikulska-Ruminska, Karolina, Anthonymuthu, Tamil S., Levkina, Anastasia, Shrivastava, Indira H., Kapralov, Alexandr A., Bayır, Hülya, Kagan, Valerian E., Bahar, Ivet
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156958/ https://www.ncbi.nlm.nih.gov/pubmed/34067535 http://dx.doi.org/10.3390/ijms22105253

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