Bintrafusp alfa (M7824), a bifunctional fusion protein targeting TGF-β and PD-L1: results from a phase I expansion cohort in patients with recurrent glioblastoma

BACKGROUND: For patients with recurrent glioblastoma (rGBM), there are few options following treatment failure with radiotherapy plus temozolomide. Bintrafusp alfa is a first-in-class bifunctional fusion protein composed of the extracellular domain of the TGF-βRII receptor (a TGF-β “trap”) fused to...

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Detalles Bibliográficos
Autores principales: Khasraw, Mustafa, Weller, Michael, Lorente, David, Kolibaba, Kathryn, Lee, Chee Khoon, Gedye, Craig, I. de La Fuente, Macarena, Vicente, David, Reardon, David A, Gan, Hui K, Scott, Andrew M, Dussault, Isabelle, Helwig, Christoph, Ojalvo, Laureen S, Gourmelon, Carole, Groves, Morris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Clinical Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156979/
https://www.ncbi.nlm.nih.gov/pubmed/34056607
http://dx.doi.org/10.1093/noajnl/vdab058

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156979/
https://www.ncbi.nlm.nih.gov/pubmed/34056607
http://dx.doi.org/10.1093/noajnl/vdab058

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