Endosomal mTORC2 Is Required for Phosphoinositide-Dependent AKT Activation in Platelet-Derived Growth Factor-Stimulated Glioma Cells

SIMPLE SUMMARY: The full activation of AKT, which is necessary for cell physiological changes, is achieved through the phosphorylation of Thr308 and Ser473 in human AKT. Here, we have addressed how AKT activation at early endosomes occurs during growth factor stimulation and how mTORC2 is recruited...

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Detalles Bibliográficos
Autores principales: Kim, Suree, Heo, Sukyeong, Brzostowski, Joseph, Kang, Dongmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8157044/
https://www.ncbi.nlm.nih.gov/pubmed/34065746
http://dx.doi.org/10.3390/cancers13102405

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8157044/
https://www.ncbi.nlm.nih.gov/pubmed/34065746
http://dx.doi.org/10.3390/cancers13102405

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