Pharmacokinetic Drug Interaction between Tofacitinib and Voriconazole in Rats

Fungal infections are prevalent in patients with immune diseases. Voriconazole, a triazole antifungal drug, inhibits the cytochromes CYP3A4 and CYP2C, and tofacitinib, a Janus kinase inhibitor for the treatment of rheumatoid arthritis, is metabolized by CYP3A4 and CYP2C19 in humans. Here, we investi...

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Detalles Bibliográficos
Autores principales: Lee, Ji-Sang, Kim, Hyo-Sung, Jung, Yong-Seob, Choi, Hyeon-Gyeom, Kim, So-Hee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8157262/
https://www.ncbi.nlm.nih.gov/pubmed/34069798
http://dx.doi.org/10.3390/pharmaceutics13050740

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8157262/
https://www.ncbi.nlm.nih.gov/pubmed/34069798
http://dx.doi.org/10.3390/pharmaceutics13050740

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