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Pharmacokinetic Drug Interaction between Tofacitinib and Voriconazole in Rats

Fungal infections are prevalent in patients with immune diseases. Voriconazole, a triazole antifungal drug, inhibits the cytochromes CYP3A4 and CYP2C, and tofacitinib, a Janus kinase inhibitor for the treatment of rheumatoid arthritis, is metabolized by CYP3A4 and CYP2C19 in humans. Here, we investi...

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Detalles Bibliográficos
Autores principales:	Lee, Ji-Sang, Kim, Hyo-Sung, Jung, Yong-Seob, Choi, Hyeon-Gyeom, Kim, So-Hee
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8157262/ https://www.ncbi.nlm.nih.gov/pubmed/34069798 http://dx.doi.org/10.3390/pharmaceutics13050740

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