Dynamic design: manipulation of millisecond timescale motions on the energy landscape of cyclophilin A

Proteins need to interconvert between many conformations in order to function, many of which are formed transiently, and sparsely populated. Particularly when the lifetimes of these states approach the millisecond timescale, identifying the relevant structures and the mechanism by which they interco...

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Detalles Bibliográficos
Autores principales: Juárez-Jiménez, Jordi, Gupta, Arun A., Karunanithy, Gogulan, Mey, Antonia S. J. S., Georgiou, Charis, Ioannidis, Harris, De Simone, Alessio, Barlow, Paul N., Hulme, Alison N., Walkinshaw, Malcolm D., Baldwin, Andrew J., Michel, Julien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8157532/
https://www.ncbi.nlm.nih.gov/pubmed/34084326
http://dx.doi.org/10.1039/c9sc04696h

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8157532/
https://www.ncbi.nlm.nih.gov/pubmed/34084326
http://dx.doi.org/10.1039/c9sc04696h

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