TET2 and DNMT3A mutations and exceptional response to 4′-thio-2′-deoxycytidine in human solid tumor models

BACKGROUND: Challenges remain on the selection of patients who potentially respond to a class of drugs that target epigenetics for cancer treatment. This study aims to investigate TET2/DNMT3A mutations and antitumor activity of a novel epigenetic agent in multiple human cancer cell lines and animal...

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Detalles Bibliográficos
Autores principales: Yang, Sherry X., Hollingshead, Melinda, Rubinstein, Larry, Nguyen, Dat, Larenjeira, Angelo B. A., Kinders, Robert J., Difilippantonio, Michael, Doroshow, James H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8157655/
https://www.ncbi.nlm.nih.gov/pubmed/34039392
http://dx.doi.org/10.1186/s13045-021-01091-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8157655/
https://www.ncbi.nlm.nih.gov/pubmed/34039392
http://dx.doi.org/10.1186/s13045-021-01091-5

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