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TET2 and DNMT3A mutations and exceptional response to 4′-thio-2′-deoxycytidine in human solid tumor models

BACKGROUND: Challenges remain on the selection of patients who potentially respond to a class of drugs that target epigenetics for cancer treatment. This study aims to investigate TET2/DNMT3A mutations and antitumor activity of a novel epigenetic agent in multiple human cancer cell lines and animal...

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Detalles Bibliográficos
Autores principales:	Yang, Sherry X., Hollingshead, Melinda, Rubinstein, Larry, Nguyen, Dat, Larenjeira, Angelo B. A., Kinders, Robert J., Difilippantonio, Michael, Doroshow, James H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8157655/ https://www.ncbi.nlm.nih.gov/pubmed/34039392 http://dx.doi.org/10.1186/s13045-021-01091-5

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