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Investigating ADR mechanisms with Explainable AI: a feasibility study with knowledge graph mining

BACKGROUND: Adverse drug reactions (ADRs) are statistically characterized within randomized clinical trials and postmarketing pharmacovigilance, but their molecular mechanism remains unknown in most cases. This is true even for hepatic or skin toxicities, which are classically monitored during drug...

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Detalles Bibliográficos
Autores principales: Bresso, Emmanuel, Monnin, Pierre, Bousquet, Cédric, Calvier, François-Elie, Ndiaye, Ndeye-Coumba, Petitpain, Nadine, Smaïl-Tabbone, Malika, Coulet, Adrien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8157660/
https://www.ncbi.nlm.nih.gov/pubmed/34039343
http://dx.doi.org/10.1186/s12911-021-01518-6