diffBUM-HMM: a robust statistical modeling approach for detecting RNA flexibility changes in high-throughput structure probing data

Advancing RNA structural probing techniques with next-generation sequencing has generated demands for complementary computational tools to robustly extract RNA structural information amidst sampling noise and variability. We present diffBUM-HMM, a noise-aware model that enables accurate detection of...

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Detalles Bibliográficos
Autores principales: Marangio, Paolo, Law, Ka Ying Toby, Sanguinetti, Guido, Granneman, Sander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8157727/
https://www.ncbi.nlm.nih.gov/pubmed/34044851
http://dx.doi.org/10.1186/s13059-021-02379-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8157727/
https://www.ncbi.nlm.nih.gov/pubmed/34044851
http://dx.doi.org/10.1186/s13059-021-02379-y

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