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Hyperoxia causes senescence and increases glycolysis in cultured lung epithelial cells

Supplemental oxygen and mechanical ventilation commonly used in premature infants may lead to chronic lung disease of prematurity, which is characterized by arrested alveolar development and dysmorphic vascular development. Hyperoxia is also known to dysregulate p53, senescence, and metabolism. Howe...

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Detalles Bibliográficos
Autores principales: Scaffa, Alejandro M., Peterson, Abigail L., Carr, Jennifer F., Garcia, David, Yao, Hongwei, Dennery, Phyllis A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8157762/
https://www.ncbi.nlm.nih.gov/pubmed/34042288
http://dx.doi.org/10.14814/phy2.14839