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Clemizole and La(3+) salts ameliorate angiotensin II‐induced glomerular hyperpermeability in vivo

Angiotensin II (Ang II) induces marked, dynamic increases in the permeability of the glomerular filtration barrier (GFB) in rats. After binding to its receptor, Ang II elicits Ca(2+) influx into cells, mediated by TRPC5 and TRPC6 (transient receptor potential canonical type 5 and 6). Clemizole and L...

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Detalles Bibliográficos
Autores principales: Dolinina, Julia, Rippe, Anna, Öberg, Carl M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8157770/
https://www.ncbi.nlm.nih.gov/pubmed/34042270
http://dx.doi.org/10.14814/phy2.14781