Radiosynthesis and Evaluation of Talazoparib and Its Derivatives as PARP-1-Targeting Agents

Poly (ADP-ribose) polymerase-1 (PARP-1) is a critical enzyme in the DNA repair process and the target of several FDA-approved inhibitors. Several of these inhibitors have been radiolabeled for non-invasive imaging of PARP-1 expression or targeted radiotherapy of PARP-1 expressing tumors. In particul...

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Detalles Bibliográficos
Autores principales: Zhou, Dong, Chen, Huaping, Mpoy, Cedric, Afrin, Sadia, Rogers, Buck E., Garbow, Joel R., Katzenellenbogen, John A., Xu, Jinbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8157854/
https://www.ncbi.nlm.nih.gov/pubmed/34069967
http://dx.doi.org/10.3390/biomedicines9050565

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8157854/
https://www.ncbi.nlm.nih.gov/pubmed/34069967
http://dx.doi.org/10.3390/biomedicines9050565

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