Computational Investigation Identified Potential Chemical Scaffolds for Heparanase as Anticancer Therapeutics

Heparanase (Hpse) is an endo-β-D-glucuronidase capable of cleaving heparan sulfate side chains. Its upregulated expression is implicated in tumor growth, metastasis and angiogenesis, thus making it an attractive target in cancer therapeutics. Currently, a few small molecule inhibitors have been repo...

Descripción completa

Detalles Bibliográficos
Autores principales: Parate, Shraddha, Kumar, Vikas, , Danishuddin, Hong, Jong Chan, Lee, Keun Woo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8157885/
https://www.ncbi.nlm.nih.gov/pubmed/34156395
http://dx.doi.org/10.3390/ijms22105311

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8157885/
https://www.ncbi.nlm.nih.gov/pubmed/34156395
http://dx.doi.org/10.3390/ijms22105311

Ejemplares similares