Epigenetic Modulation of Radiation-Induced Diacylglycerol Kinase Alpha Expression Prevents Pro-Fibrotic Fibroblast Response

SIMPLE SUMMARY: To reduce long-term fibrosis risk after radiotherapy, we demonstrated with different experimental approaches that modulation of the epigenetic pattern at the DGKA enhancer can attenuate pro-fibrotic reactions in human fibroblasts. We used (epi)genomic editing of the DGKA enhancer and...

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Detalles Bibliográficos
Autores principales: Liu, Chun-Shan, Toth, Reka, Bakr, Ali, Goyal, Ashish, Islam, Md Saiful, Breuer, Kersten, Mayakonda, Anand, Lin, Yu-Yu, Stepper, Peter, Jurkowski, Tomasz P., Veldwijk, Marlon R., Sperk, Elena, Herskind, Carsten, Lutsik, Pavlo, Weichenhan, Dieter, Plass, Christoph, Schmezer, Peter, Popanda, Odilia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8158145/
https://www.ncbi.nlm.nih.gov/pubmed/34070078
http://dx.doi.org/10.3390/cancers13102455

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8158145/
https://www.ncbi.nlm.nih.gov/pubmed/34070078
http://dx.doi.org/10.3390/cancers13102455

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