Inhibition of catechol-O-methyltransferase by natural pentacyclic triterpenes: structure–activity relationships and kinetic mechanism

Inhibitors of COMT are clinically used for the treatment of Parkinson’s disease. Here, we report the first natural pentacyclic triterpenoid-type COMT inhibitors and their structure-activity relationships and inhibition mechanism. The most potent compounds were found to be oleanic acid, betulinic aci...

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Detalles Bibliográficos
Autores principales: Wang, Fang-Yuan, Wei, Gui-Lin, Fan, Yu-Fan, Zhao, Dong-Fang, Wang, Ping, Zou, Li-Wei, Yang, Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8158265/
https://www.ncbi.nlm.nih.gov/pubmed/34030574
http://dx.doi.org/10.1080/14756366.2021.1928112

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8158265/
https://www.ncbi.nlm.nih.gov/pubmed/34030574
http://dx.doi.org/10.1080/14756366.2021.1928112

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