Substance P Serves as a Balanced Agonist for MRGPRX2 and a Single Tyrosine Residue Is Required for β-Arrestin Recruitment and Receptor Internalization

The neuropeptide substance P (SP) mediates neurogenic inflammation and pain and contributes to atopic dermatitis in mice through the activation of mast cells (MCs) via Mas-related G protein-coupled receptor (GPCR)-B2 (MrgprB2, human ortholog MRGPRX2). In addition to G proteins, certain MRGPRX2 agoni...

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Detalles Bibliográficos
Autores principales: Chompunud Na Ayudhya, Chalatip, Amponnawarat, Aetas, Ali, Hydar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8158387/
https://www.ncbi.nlm.nih.gov/pubmed/34070125
http://dx.doi.org/10.3390/ijms22105318

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8158387/
https://www.ncbi.nlm.nih.gov/pubmed/34070125
http://dx.doi.org/10.3390/ijms22105318

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