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Development and In Vitro Evaluation of Controlled Release Viagra(®) Containing Poloxamer-188 Using Gastroplus(™) PBPK Modeling Software for In Vivo Predictions and Pharmacokinetic Assessments
Sildenafil is the active substance in Viagra(®) tablets, which is approved by the FDA to treat sexual dysfunction in men. Poor solubility and short half-life, however, can limit the span of its effectiveness. Therefore, this study focused on an oral controlled release matrix system with the aim to i...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8158482/ https://www.ncbi.nlm.nih.gov/pubmed/34070160 http://dx.doi.org/10.3390/ph14050479 |