CUX1 Enhances Pancreatic Cancer Formation by Synergizing with KRAS and Inducing MEK/ERK-Dependent Proliferation

SIMPLE SUMMARY: In pancreatic cancer, CUX1 acts as an important mediator of tumor cell proliferation and resistance to apoptosis. Using two different mouse models for the prevalent CUX1 isoforms p200 and p110, we identified p110 CUX1 as the major isoform promoting pancreatic cancer formation in the...

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Detalles Bibliográficos
Autores principales: Griesmann, Heidi, Mühl, Sebastian, Riedel, Jan, Theuerkorn, Katharina, Sipos, Bence, Esposito, Irene, Vanden Heuvel, Gregory B., Michl, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8158495/
https://www.ncbi.nlm.nih.gov/pubmed/34070180
http://dx.doi.org/10.3390/cancers13102462

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8158495/
https://www.ncbi.nlm.nih.gov/pubmed/34070180
http://dx.doi.org/10.3390/cancers13102462

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