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Real-World Use of Azathioprine Metabolites Changes Clinical Management of Inflammatory Bowel Disease
BACKGROUND: Thiopurines such as 6-mercaptopurine and azathioprine have complex metabolism, resulting in significant inter-individual differences in clinical efficacy and risk of drug toxicity, making conventional weight-based dosing inaccurate and potentially unsafe. Therapeutic drug monitoring (TDM...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8158651/ https://www.ncbi.nlm.nih.gov/pubmed/34056527 http://dx.doi.org/10.1093/jcag/gwaa005 |