The Glitazone Class of Drugs as Carbonic Anhydrase Inhibitors—A Spin-Off Discovery from Fragment Screening

The approved drugs that target carbonic anhydrases (CA, EC 4.2.1.1), a family of zinc metalloenzymes, comprise almost exclusively of primary sulfonamides (R-SO(2)NH(2)) as the zinc binding chemotype. New clinical applications for CA inhibitors, particularly for hard-to-treat cancers, has driven a gr...

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Detalles Bibliográficos
Autores principales: Mueller, Sarah L., Chrysanthopoulos, Panagiotis K., Halili, Maria A., Hepburn, Caryn, Nebl, Tom, Supuran, Claudiu T., Nocentini, Alessio, Peat, Thomas S., Poulsen, Sally-Ann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8158703/
https://www.ncbi.nlm.nih.gov/pubmed/34070212
http://dx.doi.org/10.3390/molecules26103010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8158703/
https://www.ncbi.nlm.nih.gov/pubmed/34070212
http://dx.doi.org/10.3390/molecules26103010

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