Rational Design of Novel Anticancer Small-Molecule RNA m6A Demethylase ALKBH5 Inhibitors

[Image: see text] The RNA 6-N-methyladenosine (m6A) demethylase ALKBH5 has been shown to be oncogenic in several cancer types, including leukemia and glioblastoma. We present here the target-tailored development and first evaluation of the antiproliferative effects of new ALKBH5 inhibitors. Two comp...

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Detalles Bibliográficos
Autores principales: Selberg, Simona, Seli, Neinar, Kankuri, Esko, Karelson, Mati
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8158789/
https://www.ncbi.nlm.nih.gov/pubmed/34056479
http://dx.doi.org/10.1021/acsomega.1c01289

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8158789/
https://www.ncbi.nlm.nih.gov/pubmed/34056479
http://dx.doi.org/10.1021/acsomega.1c01289

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