Radical Scavenging Activity of Natural Anthraquinones: a Theoretical Insight
[Image: see text] Anthraquinones (ANQs) isolated from Paederia plants are known to have antidiarrheal, antitussive, anthelmintic, analgesic, anti-inflammatory, antihyperlipidemic, antihyperglycaemic, and antimicrobial activities. The antioxidant properties were also noted but not confirmed thus far....
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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American Chemical Society
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8158809/ https://www.ncbi.nlm.nih.gov/pubmed/34056486 http://dx.doi.org/10.1021/acsomega.1c01448 |
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author | Trung, Nguyen Quang Thong, Nguyen Minh Cuong, Dao Hung Manh, Tran Duc Hoang, Loc Phuoc Hien, Nguyen Khoa Nam, Pham Cam Quang, Duong Tuan Mechler, Adam Vo, Quan V. |
author_facet | Trung, Nguyen Quang Thong, Nguyen Minh Cuong, Dao Hung Manh, Tran Duc Hoang, Loc Phuoc Hien, Nguyen Khoa Nam, Pham Cam Quang, Duong Tuan Mechler, Adam Vo, Quan V. |
author_sort | Trung, Nguyen Quang |
collection | PubMed |
description | [Image: see text] Anthraquinones (ANQs) isolated from Paederia plants are known to have antidiarrheal, antitussive, anthelmintic, analgesic, anti-inflammatory, antihyperlipidemic, antihyperglycaemic, and antimicrobial activities. The antioxidant properties were also noted but not confirmed thus far. In this study, the superoxide and hydroperoxide radical scavenging activities of six ANQs were evaluated using a computational approach. The results suggest that the ANQs exhibit low HOO(•) antiradical activity in all environments, including the gas phase (k < 10(2) M(–1) s(–1)). In contrast, the ANQs might exert excellent O(2)(•–) radical scavenging activity, particularly in aqueous solution. The rate constants of the superoxide anion scavenging in water (at pH = 7.4) range from 3.42 × 10(6) to 3.70 × 10(8) M(–1) s(–1). Compared with typical antioxidants such as ascorbic acid and quercetin, the superoxide anion scavenging activity of ANQs is significantly higher. Thus, the ANQs are promising O(2)(•–) radical scavengers in polar media. |
format | Online Article Text |
id | pubmed-8158809 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-81588092021-05-28 Radical Scavenging Activity of Natural Anthraquinones: a Theoretical Insight Trung, Nguyen Quang Thong, Nguyen Minh Cuong, Dao Hung Manh, Tran Duc Hoang, Loc Phuoc Hien, Nguyen Khoa Nam, Pham Cam Quang, Duong Tuan Mechler, Adam Vo, Quan V. ACS Omega [Image: see text] Anthraquinones (ANQs) isolated from Paederia plants are known to have antidiarrheal, antitussive, anthelmintic, analgesic, anti-inflammatory, antihyperlipidemic, antihyperglycaemic, and antimicrobial activities. The antioxidant properties were also noted but not confirmed thus far. In this study, the superoxide and hydroperoxide radical scavenging activities of six ANQs were evaluated using a computational approach. The results suggest that the ANQs exhibit low HOO(•) antiradical activity in all environments, including the gas phase (k < 10(2) M(–1) s(–1)). In contrast, the ANQs might exert excellent O(2)(•–) radical scavenging activity, particularly in aqueous solution. The rate constants of the superoxide anion scavenging in water (at pH = 7.4) range from 3.42 × 10(6) to 3.70 × 10(8) M(–1) s(–1). Compared with typical antioxidants such as ascorbic acid and quercetin, the superoxide anion scavenging activity of ANQs is significantly higher. Thus, the ANQs are promising O(2)(•–) radical scavengers in polar media. American Chemical Society 2021-05-13 /pmc/articles/PMC8158809/ /pubmed/34056486 http://dx.doi.org/10.1021/acsomega.1c01448 Text en © 2021 The Authors. Published by American Chemical Society Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Trung, Nguyen Quang Thong, Nguyen Minh Cuong, Dao Hung Manh, Tran Duc Hoang, Loc Phuoc Hien, Nguyen Khoa Nam, Pham Cam Quang, Duong Tuan Mechler, Adam Vo, Quan V. Radical Scavenging Activity of Natural Anthraquinones: a Theoretical Insight |
title | Radical Scavenging Activity of Natural Anthraquinones:
a Theoretical Insight |
title_full | Radical Scavenging Activity of Natural Anthraquinones:
a Theoretical Insight |
title_fullStr | Radical Scavenging Activity of Natural Anthraquinones:
a Theoretical Insight |
title_full_unstemmed | Radical Scavenging Activity of Natural Anthraquinones:
a Theoretical Insight |
title_short | Radical Scavenging Activity of Natural Anthraquinones:
a Theoretical Insight |
title_sort | radical scavenging activity of natural anthraquinones:
a theoretical insight |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8158809/ https://www.ncbi.nlm.nih.gov/pubmed/34056486 http://dx.doi.org/10.1021/acsomega.1c01448 |
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