Bile acid synthesis, modulation, and dementia: A metabolomic, transcriptomic, and pharmacoepidemiologic study

BACKGROUND: While Alzheimer disease (AD) and vascular dementia (VaD) may be accelerated by hypercholesterolemia, the mechanisms underlying this association are unclear. We tested whether dysregulation of cholesterol catabolism, through its conversion to primary bile acids (BAs), was associated with...

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Detalles Bibliográficos
Autores principales: Varma, Vijay R., Wang, Youjin, An, Yang, Varma, Sudhir, Bilgel, Murat, Doshi, Jimit, Legido-Quigley, Cristina, Delgado, João C., Oommen, Anup M., Roberts, Jackson A., Wong, Dean F., Davatzikos, Christos, Resnick, Susan M., Troncoso, Juan C., Pletnikova, Olga, O’Brien, Richard, Hak, Eelko, Baak, Brenda N., Pfeiffer, Ruth, Baloni, Priyanka, Mohmoudiandehkordi, Siamak, Nho, Kwangsik, Kaddurah-Daouk, Rima, Bennett, David A., Gadalla, Shahinaz M., Thambisetty, Madhav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8158920/
https://www.ncbi.nlm.nih.gov/pubmed/34043628
http://dx.doi.org/10.1371/journal.pmed.1003615

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8158920/
https://www.ncbi.nlm.nih.gov/pubmed/34043628
http://dx.doi.org/10.1371/journal.pmed.1003615

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