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Precipitation-free high-affinity multivalent binding by inline lectin ligands

Multivalent ligand–protein interactions are a key concept in biology mediating, for example, signalling and adhesion. Multivalent ligands often have tremendously increased binding affinities. However, they also can cause crosslinking of receptor molecules leading to precipitation of ligand–receptor...

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Detalles Bibliográficos
Autores principales: Rohse, Philipp, Weickert, Sabrina, Drescher, Malte, Wittmann, Valentin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8159369/
https://www.ncbi.nlm.nih.gov/pubmed/34122979
http://dx.doi.org/10.1039/d0sc01744b