Autism-like social deficit generated by Dock4 deficiency is rescued by restoration of Rac1 activity and NMDA receptor function

Genetic studies of autism spectrum disorder (ASD) have revealed multigene variations that converge on synaptic dysfunction. DOCK4, a gene at 7q31.1 that encodes the Rac1 guanine nucleotide exchange factor Dock4, has been identified as a risk gene for ASD and other neuropsychiatric disorders. However...

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Detalles Bibliográficos
Autores principales: Guo, Daji, Peng, Yinghui, Wang, Laijian, Sun, Xiaoyu, Wang, Xiaojun, Liang, Chunmei, Yang, Xiaoman, Li, Shengnan, Xu, Junyu, Ye, Wen-Cai, Jiang, Bin, Shi, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8159750/
https://www.ncbi.nlm.nih.gov/pubmed/31388105
http://dx.doi.org/10.1038/s41380-019-0472-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8159750/
https://www.ncbi.nlm.nih.gov/pubmed/31388105
http://dx.doi.org/10.1038/s41380-019-0472-7

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