Acid ceramidase controls apoptosis and increases autophagy in human melanoma cells treated with doxorubicin

Acid ceramidase (AC) is a lysosomal hydrolase encoded by the ASAH1 gene, which cleaves ceramides into sphingosine and fatty acid. AC is expressed at high levels in most human melanoma cell lines and may confer resistance against chemotherapeutic agents. One such agent, doxorubicin, was shown to incr...

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Detalles Bibliográficos
Autores principales: Lai, Michele, Amato, Rachele, La Rocca, Veronica, Bilgin, Mesut, Freer, Giulia, Spezia, Piergiorgio, Quaranta, Paola, Piomelli, Daniele, Pistello, Mauro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8159975/
https://www.ncbi.nlm.nih.gov/pubmed/34045496
http://dx.doi.org/10.1038/s41598-021-90219-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8159975/
https://www.ncbi.nlm.nih.gov/pubmed/34045496
http://dx.doi.org/10.1038/s41598-021-90219-1

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