Small molecule inhibitors of the mitochondrial ClpXP protease possess cytostatic potential and re-sensitize chemo-resistant cancers

The human mitochondrial ClpXP protease complex (HsClpXP) has recently attracted major attention as a target for novel anti-cancer therapies. Despite its important role in disease progression, the cellular role of HsClpXP is poorly characterized and only few small molecule inhibitors have been report...

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Detalles Bibliográficos
Autores principales: Meßner, Martina, Mandl, Melanie M., Hackl, Mathias W., Reinhardt, Till, Ardelt, Maximilian A., Szczepanowska, Karolina, Frädrich, Julian E., Waschke, Jens, Jeremias, Irmela, Fux, Anja, Stahl, Matthias, Vollmar, Angelika M., Sieber, Stephan A., Pachmayr, Johanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8160014/
https://www.ncbi.nlm.nih.gov/pubmed/34045646
http://dx.doi.org/10.1038/s41598-021-90801-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8160014/
https://www.ncbi.nlm.nih.gov/pubmed/34045646
http://dx.doi.org/10.1038/s41598-021-90801-7

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