A hybrid modeling approach for assessing mechanistic models of small molecule partitioning in vivo using a machine learning-integrated modeling platform

Prediction of the first-in-human dosing regimens is a critical step in drug development and requires accurate quantitation of drug distribution. Traditional in vivo studies used to characterize clinical candidate’s volume of distribution are error-prone, time- and cost-intensive and lack reproducibi...

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Detalles Bibliográficos
Autores principales: Antontsev, Victor, Jagarapu, Aditya, Bundey, Yogesh, Hou, Hypatia, Khotimchenko, Maksim, Walsh, Jason, Varshney, Jyotika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8160209/
https://www.ncbi.nlm.nih.gov/pubmed/34045592
http://dx.doi.org/10.1038/s41598-021-90637-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8160209/
https://www.ncbi.nlm.nih.gov/pubmed/34045592
http://dx.doi.org/10.1038/s41598-021-90637-1

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