Reversible Changes in BDNF Expression in MK-801-Induced Hippocampal Astrocytes Through NMDAR/PI3K/ERK Signaling

Dizocilpine (MK-801), a non-competitive N-methyl-D-aspartic acid receptor (NMDA-R) antagonist, can induce schizophrenia-like symptoms in healthy individuals, implicating NMDA-R hypofunction in disease pathogenesis. Brain-derived neurotrophic factor (BDNF) is also implicated in schizophrenia, and exp...

Descripción completa

Detalles Bibliográficos
Autores principales: Yu, Wenjuan, Fang, Hongwei, Zhang, Lei, Hu, Miaowen, He, Sidi, Li, Huafang, Zhu, Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8160225/
https://www.ncbi.nlm.nih.gov/pubmed/34054433
http://dx.doi.org/10.3389/fncel.2021.672136

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8160225/
https://www.ncbi.nlm.nih.gov/pubmed/34054433
http://dx.doi.org/10.3389/fncel.2021.672136

Ejemplares similares