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Reversible Changes in BDNF Expression in MK-801-Induced Hippocampal Astrocytes Through NMDAR/PI3K/ERK Signaling

Dizocilpine (MK-801), a non-competitive N-methyl-D-aspartic acid receptor (NMDA-R) antagonist, can induce schizophrenia-like symptoms in healthy individuals, implicating NMDA-R hypofunction in disease pathogenesis. Brain-derived neurotrophic factor (BDNF) is also implicated in schizophrenia, and exp...

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Detalles Bibliográficos
Autores principales:	Yu, Wenjuan, Fang, Hongwei, Zhang, Lei, Hu, Miaowen, He, Sidi, Li, Huafang, Zhu, Hao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8160225/ https://www.ncbi.nlm.nih.gov/pubmed/34054433 http://dx.doi.org/10.3389/fncel.2021.672136

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