Cargando…

Translational Block in Stroke: A Constructive and “Out-of-the-Box” Reappraisal

Why can we still not translate preclinical research to clinical treatments for acute strokes? Despite > 1000 successful preclinical studies, drugs, and concepts for acute stroke, only two have reached clinical translation. This is the translational block. Yet, we continue to routinely model strok...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lourbopoulos, Athanasios, Mourouzis, Iordanis, Xinaris, Christodoulos, Zerva, Nefeli, Filippakis, Konstantinos, Pavlopoulos, Angelos, Pantos, Constantinos
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8160233/ https://www.ncbi.nlm.nih.gov/pubmed/34054413 http://dx.doi.org/10.3389/fnins.2021.652403

Ejemplares similares

Triiodothyronine prevents tissue hypoxia in experimental sepsis: potential therapeutic implications
por: Mourouzis, Iordanis S., et al.
Publicado: (2021)

Effects of Thyroid Hormone on Tissue Hypoxia: Relevance to Sepsis Therapy
por: Lourbopoulos, Athanasios I., et al.
Publicado: (2021)

Thyroid Hormone and Heart Failure: Charting Known Pathways for Cardiac Repair/Regeneration
por: Mantzouratou, Polyxeni, et al.
Publicado: (2023)

Effects of T3 Administration on Ex Vivo Rat Hearts Subjected to Normothermic Perfusion: Therapeutic Implications in Donor Heart Preservation and Repair
por: Mourouzis, Iordanis, et al.
Publicado: (2023)

The Emerging Role of TRα1 in Cardiac Repair: Potential Therapeutic Implications
por: Pantos, Constantinos, et al.
Publicado: (2014)

Thyroid Hormone and Tissue Repair: New Tricks for an Old Hormone?
por: Mourouzis, Iordanis, et al.
Publicado: (2013)

Use of triiodothyronine to treat critically ill COVID-19 patients: a new clinical trial
por: Pantos, Constantinos, et al.
Publicado: (2020)

Cell-Type-Dependent Thyroid Hormone Effects on Glioma Tumor Cell Lines
por: Alexandros, Liappas, et al.
Publicado: (2011)

Erratum to “Cell-Type-Dependent Thyroid Hormone Effects on Glioma Tumor Cell Lines”
por: Liappas, Alexandros, et al.
Publicado: (2012)

Principal Aspects Regarding the Maintenance of Mammalian Mitochondrial Genome Integrity
por: Vasileiou, Panagiotis V. S., et al.
Publicado: (2017)

Thyroid Hormone and Cardiac Disease: From Basic Concepts to Clinical Application
por: Mourouzis, Iordanis, et al.
Publicado: (2011)

Triiodothyronine for the treatment of critically ill patients with COVID-19 infection: A structured summary of a study protocol for a randomised controlled trial
por: Pantos, Constantinos, et al.
Publicado: (2020)

Changes in Thyroid Hormone Signaling Mediate Cardiac Dysfunction in the Tg197 Mouse Model of Arthritis: Potential Therapeutic Implications
por: Ntari, Lydia, et al.
Publicado: (2021)

Time-dependent and independent effects of thyroid hormone administration following myocardial infarction in rats
por: Iliopoulou, Ioanna, et al.
Publicado: (2018)

Think Out of the Box, Think Out of the Eye Reappraisal of HIV/AIDS Retinopathy
por: Pichi, Francesco, et al.
Publicado: (2014)

The Potential of Thyroid Hormone Therapy in Severe COVID-19: Rationale and Preliminary Evidence
por: Mourouzis, Iordanis, et al.
Publicado: (2022)

Are Thyroid Hormone and Tumor Cell Proliferation in Human Breast Cancers Positive for HER2 Associated?
por: Mourouzis, Iordanis, et al.
Publicado: (2015)

Sympathetic and Vagal Responses Elicited by Acute Stress in Rats
por: Mouchtouri, Eleni-Taxiarchia, et al.
Publicado: (2020)

Endothelin Modulates Rhythm Disturbances and Autonomic Responses to Acute Emotional Stress in Rats
por: Mouchtouri, Eleni-Taxiarchia, et al.
Publicado: (2023)

Comorbid TNF-mediated heart valve disease and chronic polyarthritis share common mesenchymal cell-mediated aetiopathogenesis
por: Ntari, Lydia, et al.
Publicado: (2018)

Significant rise in neck infections progressing to descending necrotizing mediastinitis during the COVID-19 pandemic quarantine
por: Parara, Eleni, et al.
Publicado: (2021)

Diabetic Nephropathy: Novel Molecular Mechanisms and Therapeutic Targets
por: Zoja, Carlamaria, et al.
Publicado: (2020)

The effect of slow spaced eating on hunger and satiety in overweight and obese patients with type 2 diabetes mellitus
por: Angelopoulos, Theodoros, et al.
Publicado: (2014)

Kidney Organoids as Disease Models: Strengths, Weaknesses and Perspectives
por: Romero-Guevara, Ricardo, et al.
Publicado: (2020)

Thyroid Hormone Signalling in Human Evolution and Disease: A Novel Hypothesis
por: Mantzouratou, Polyxeni, et al.
Publicado: (2021)

A protocol for the generation of EPO - Producing neural crest cells from human induced pluripotent stem cells
por: Lavecchia, Angelo Michele, et al.
Publicado: (2022)

Ectopic bone formation and systemic bone loss in a transmembrane TNF-driven model of human spondyloarthritis
por: Christodoulou-Vafeiadou, Eleni, et al.
Publicado: (2020)

Cell Hypertrophy: A “Biophysical Roadblock” to Reversing Kidney Injury
por: Lavecchia, Angelo Michele, et al.
Publicado: (2022)

SGLT-2 Inhibitors and the Inflammasome: What’s Next in the 21st Century?
por: Kounatidis, Dimitris, et al.
Publicado: (2023)

Flash out of the box
por: Hoekman, Robert
Publicado: (2004)

Microglia in action: how aging and injury can change the brain’s guardians
por: Lourbopoulos, Athanasios, et al.
Publicado: (2015)

Fire phone : out of the box
por: Sawyer, Brian
Publicado: (2014)

Windows 8: Out of the Box
por: Halsey, Mike
Publicado: (2012)

Mac Design out of the box
por: Shalat, Andrew
Publicado: (2006)

NOOK tablet: out of the box
por: Gralla, Preston, et al.
Publicado: (2012)

Kindle Fire: out of the box
por: Sawyer, Brian
Publicado: (2012)

Cardiotrophin-1 in Asymptomatic Hypertensive Patients With Mild Diastolic Dysfunction: Potential Prognostic Value in Early Stages of Hypertensive Heart Disease
por: Vlahodimitris, Ioannis, et al.
Publicado: (2023)

Clinical review: Reappraising the concept of immediate defibrillatory attempts for out-of-hospital ventricular fibrillation
por: Pepe, Paul E, et al.
Publicado: (2004)

Windows 8.1: out of the box
por: Halsey, Mike
Publicado: (2013)

Out-of-the-box templates of Drupal websites
por: Betz, Tobias
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_c8gf7fb6lnijqgceln29hscugg