Whole-Body Prolyl Hydroxylase Domain (PHD) 3 Deficiency Increased Plasma Lipids and Hematocrit Without Impacting Plaque Size in Low-Density Lipoprotein Receptor Knockout Mice

Background and aims: Atherosclerosis is an important cause of clinical cardiovascular events. Atherosclerotic plaques are hypoxic, and reoxygenation improves plaque phenotype. Central players in hypoxia are hypoxia inducible factors (HIF) and their regulators, HIF-prolyl hydroxylase (PHD) isoforms 1...

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Detalles Bibliográficos
Autores principales: Demandt, Jasper A. F., van Kuijk, Kim, Theelen, Thomas L., Marsch, Elke, Heffron, Sean P., Fisher, Edward A., Carmeliet, Peter, Biessen, Erik A. L., Sluimer, Judith C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8160238/
https://www.ncbi.nlm.nih.gov/pubmed/34055796
http://dx.doi.org/10.3389/fcell.2021.664258

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8160238/
https://www.ncbi.nlm.nih.gov/pubmed/34055796
http://dx.doi.org/10.3389/fcell.2021.664258

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