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White-tailed deer S96 prion protein does not support stable in vitro propagation of most common CWD strains
PrP(C) variation at residue 96 (G/S) plays an important role in the epidemiology of chronic wasting disease (CWD) in exposed white-tailed deer populations. In vivo studies have demonstrated the protective effect of serine at codon 96, which hinders the propagation of common CWD strains when expresse...
Autores principales: | Otero, Alicia, Duque Velásquez, Camilo, Aiken, Judd, McKenzie, Debbie |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8160261/ https://www.ncbi.nlm.nih.gov/pubmed/34045540 http://dx.doi.org/10.1038/s41598-021-90606-8 |
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