Effect of 4-week physical exercises on tryptophan, kynurenine and kynurenic acid content in human sweat

The aim of the study was the detection of TRP, kynurenine (KYN), and kynurenic acid (KYNA) in human sweat, and determining whether physical activity affects their content in this secrete. Two different methods were used simultaneously—collection of sweat by means of an absorption pad from the inter...

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Autores principales: Saran, Tomasz, Turska, Monika, Kocki, Tomasz, Zawadka, Magdalena, Zieliński, Grzegorz, Turski, Waldemar A., Gawda, Piotr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8160349/
https://www.ncbi.nlm.nih.gov/pubmed/34045580
http://dx.doi.org/10.1038/s41598-021-90616-6
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author Saran, Tomasz
Turska, Monika
Kocki, Tomasz
Zawadka, Magdalena
Zieliński, Grzegorz
Turski, Waldemar A.
Gawda, Piotr
author_facet Saran, Tomasz
Turska, Monika
Kocki, Tomasz
Zawadka, Magdalena
Zieliński, Grzegorz
Turski, Waldemar A.
Gawda, Piotr
author_sort Saran, Tomasz
collection PubMed
description The aim of the study was the detection of TRP, kynurenine (KYN), and kynurenic acid (KYNA) in human sweat, and determining whether physical activity affects their content in this secrete. Two different methods were used simultaneously—collection of sweat by means of an absorption pad from the inter scapular region, and collection of a drop of sweat from the region of the forehead. Quantitative determinations of TRP, KYN and KYNA were performed using high performance liquid chromatography with ultraviolet and fluorescence detection. Determinations of sodium was carried out by the method of inductively coupled plasma collision/reaction cell ionization mass spectrophotometry. It was found that physical exercises evoked a decrease in the amount of KYN, and an increase in the amount of KYNA in sweat recorded on day 14, but not on day 28 of training. It appears that physical exercises result in a long-term increase in the kynurenine transaminase activity responsible for the formation of KYNA from KYN. Based on this results, it can be suggested that measurement of TRP, KYN and KYNA in sweat may have diagnostic potential and may help to establish an exercise regime appropriate for the age, gender and health status of rehabilitation patients.
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spelling pubmed-81603492021-06-01 Effect of 4-week physical exercises on tryptophan, kynurenine and kynurenic acid content in human sweat Saran, Tomasz Turska, Monika Kocki, Tomasz Zawadka, Magdalena Zieliński, Grzegorz Turski, Waldemar A. Gawda, Piotr Sci Rep Article The aim of the study was the detection of TRP, kynurenine (KYN), and kynurenic acid (KYNA) in human sweat, and determining whether physical activity affects their content in this secrete. Two different methods were used simultaneously—collection of sweat by means of an absorption pad from the inter scapular region, and collection of a drop of sweat from the region of the forehead. Quantitative determinations of TRP, KYN and KYNA were performed using high performance liquid chromatography with ultraviolet and fluorescence detection. Determinations of sodium was carried out by the method of inductively coupled plasma collision/reaction cell ionization mass spectrophotometry. It was found that physical exercises evoked a decrease in the amount of KYN, and an increase in the amount of KYNA in sweat recorded on day 14, but not on day 28 of training. It appears that physical exercises result in a long-term increase in the kynurenine transaminase activity responsible for the formation of KYNA from KYN. Based on this results, it can be suggested that measurement of TRP, KYN and KYNA in sweat may have diagnostic potential and may help to establish an exercise regime appropriate for the age, gender and health status of rehabilitation patients. Nature Publishing Group UK 2021-05-27 /pmc/articles/PMC8160349/ /pubmed/34045580 http://dx.doi.org/10.1038/s41598-021-90616-6 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Saran, Tomasz
Turska, Monika
Kocki, Tomasz
Zawadka, Magdalena
Zieliński, Grzegorz
Turski, Waldemar A.
Gawda, Piotr
Effect of 4-week physical exercises on tryptophan, kynurenine and kynurenic acid content in human sweat
title Effect of 4-week physical exercises on tryptophan, kynurenine and kynurenic acid content in human sweat
title_full Effect of 4-week physical exercises on tryptophan, kynurenine and kynurenic acid content in human sweat
title_fullStr Effect of 4-week physical exercises on tryptophan, kynurenine and kynurenic acid content in human sweat
title_full_unstemmed Effect of 4-week physical exercises on tryptophan, kynurenine and kynurenic acid content in human sweat
title_short Effect of 4-week physical exercises on tryptophan, kynurenine and kynurenic acid content in human sweat
title_sort effect of 4-week physical exercises on tryptophan, kynurenine and kynurenic acid content in human sweat
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8160349/
https://www.ncbi.nlm.nih.gov/pubmed/34045580
http://dx.doi.org/10.1038/s41598-021-90616-6
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