Cargando…

Human stem cells harboring a suicide gene improve the safety and standardisation of neural transplants in Parkinsonian rats

Despite advancements in human pluripotent stem cells (hPSCs) differentiation protocols to generate appropriate neuronal progenitors suitable for transplantation in Parkinson’s disease, resultant grafts contain low proportions of dopamine neurons. Added to this is the tumorigenic risk associated with...

Descripción completa

Detalles Bibliográficos
Autores principales:	de Luzy, Isabelle R., Law, Kevin C. L., Moriarty, Niamh, Hunt, Cameron P. J., Durnall, Jennifer C., Thompson, Lachlan H., Nagy, Andras, Parish, Clare L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8160354/ https://www.ncbi.nlm.nih.gov/pubmed/34045451 http://dx.doi.org/10.1038/s41467-021-23125-9

Ejemplares similares

Transcriptional Profiling of Xenogeneic Transplants: Examining Human Pluripotent Stem Cell-Derived Grafts in the Rodent Brain
por: Bye, Christopher R., et al.
Publicado: (2019)

Understanding and modeling regional specification of the human ganglionic eminence
por: Hunt, Cameron P.J., et al.
Publicado: (2023)

A PITX3-EGFP Reporter Line Reveals Connectivity of Dopamine and Non-dopamine Neuronal Subtypes in Grafts Generated from Human Embryonic Stem Cells
por: Niclis, Jonathan C., et al.
Publicado: (2017)

Specification of murine ground state pluripotent stem cells to regional neuronal populations
por: Alsanie, Walaa F., et al.
Publicado: (2017)

Assisted Suicide in Parkinsonian Disorders
por: Nuebling, Georg S., et al.
Publicado: (2021)

Long‐Distance Axonal Growth and Protracted Functional Maturation of Neurons Derived from Human Induced Pluripotent Stem Cells After Intracerebral Transplantation
por: Niclis, Jonathan C., et al.
Publicado: (2017)

Developing stem cell-based therapies for neural repair
por: Parish, Clare L., et al.
Publicado: (2013)

Unprecedented Potential for Neural Drug Discovery Based on Self-Organizing hiPSC Platforms
por: Cota-Coronado, Agustín, et al.
Publicado: (2020)

Efficiently Specified Ventral Midbrain Dopamine Neurons from Human Pluripotent Stem Cells Under Xeno‐Free Conditions Restore Motor Deficits in Parkinsonian Rodents
por: Niclis, Jonathan C., et al.
Publicado: (2016)

Extracellular Matrix Biomimetic Hydrogels, Encapsulated with Stromal Cell-Derived Factor 1, Improve the Composition of Foetal Tissue Grafts in a Rodent Model of Parkinson’s Disease
por: Penna, Vanessa, et al.
Publicado: (2022)

Embryonic stem cells go from bench to bedside for Parkinson’s disease
por: Parish, Clare L., et al.
Publicado: (2021)

FGF-MAPK signaling regulates human deep-layer corticogenesis
por: Gantner, Carlos W., et al.
Publicado: (2021)

STANDARDISATION OF ELADICHOORNAM
por: Thankamma, A., et al.
Publicado: (1998)

Creation of GMP-Compliant iPSCs From Banked Umbilical Cord Blood
por: Tian, Pei, et al.
Publicado: (2022)

STANDARDISATION OF THALEESAPATRADI CHURNAM
por: Thankamma, A., et al.
Publicado: (1995)

Modeling the origin of parkinsonian tremor
por: Dovzhenok, Andrei, et al.
Publicado: (2010)

STANDARDISATION OF SOMARAJEE TAILA
por: Agarwal, R G, et al.
Publicado: (1991)

Attempted Suicide in a Parkinsonian Patient Treated with DBS of the VIM and High Dose Carbidopa-Levodopa
por: Ayobello, Ayotunde, et al.
Publicado: (2019)

An Optimized Protocol for the Generation of Midbrain Dopamine Neurons under Defined Conditions
por: Gantner, Carlos W., et al.
Publicado: (2020)

Standard errors of non-standardised and age-standardised relative survival of cancer patients
por: Jansen, L, et al.
Publicado: (2012)

Ischemic Injury Does Not Stimulate Striatal Neuron Replacement Even during Periods of Active Striatal Neurogenesis
por: Ermine, Charlotte M., et al.
Publicado: (2020)

A Case of Encephalitis Lethargica with Parkinsonian Syndrome
por: De, J. C.
Publicado: (1923)

Over-Expression of Meteorin Drives Gliogenesis Following Striatal Injury
por: Wright, Jordan L., et al.
Publicado: (2016)

Autonomic Dysfunctions in Parkinsonian Disorders
por: Bae, Hyo-Jin, et al.
Publicado: (2009)

Assessing Bradykinesia in Parkinsonian Disorders
por: Pal, Gian, et al.
Publicado: (2013)

TSPO imaging in parkinsonian disorders
por: Gerhard, Alexander
Publicado: (2016)

Opioid Overdose With Parkinsonian Features
por: Cohen, Paul, et al.
Publicado: (2019)

Epidemiology of atypical parkinsonian syndromes
por: Lo, Raymond Y.
Publicado: (2021)

STANDARDISATION OF KARPURASAVA
por: Alam, Muzaffer, et al.
Publicado: (1994)

STANDARDISATION OF DIKAMALI
por: Anandakumar, A., et al.
Publicado: (1984)

The Standardisation of Sera
Publicado: (1921)

Neuroanatomical and Microglial Alterations in the Striatum of Levodopa-Treated, Dyskinetic Hemi-Parkinsonian Rats
por: Fletcher, Edward J. R., et al.
Publicado: (2020)

Fracture Risk Assessment in Atypical Parkinsonian Syndromes
por: Kobylecki, Christopher, et al.
Publicado: (2021)

Basal ganglia–cortical interactions in Parkinsonian patients
por: Marreiros, André C., et al.
Publicado: (2013)

Synchronization of the parkinsonian globus pallidus by gap junctions
por: Schwab, Bettina C, et al.
Publicado: (2014)

The effects of safinamide according to gender in Chinese parkinsonian patients
por: Pellecchia, M. T., et al.
Publicado: (2023)

STUDIES ON STANDARDISATION OF TRIBHUVANAKIRTI RASA
por: Agrawal, R.G., et al.
Publicado: (1996)

The nature of tremor circuits in parkinsonian and essential tremor
por: Cagnan, Hayriye, et al.
Publicado: (2014)

Excess mortality by suicide in high-risk subgroups of suicide attempters: a prospective study of standardised mortality rates in suicide attempters examined at a medical emergency inpatient unit
por: Probert-Lindström, Sara, et al.
Publicado: (2022)

Potential Mechanisms for Imperfect Synchronization in Parkinsonian Basal Ganglia
por: Park, Choongseok, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_1l2rjadchostuucjfe7556letk