Cargando…

Enhanced Expression of Human Epididymis Protein 4 (HE4) Reflecting Pro-Inflammatory Status Is Regulated by CFTR in Cystic Fibrosis Bronchial Epithelial Cells

Decreased human epididymis protein 4 (HE4) plasma levels were reported in cystic fibrosis (CF) patients under CFTR potentiator ivacaftor therapy, which inversely correlated with lung function improvement. In this study, we investigated whether HE4 expression was affected via modulation of CFTR funct...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bene, Zsolt, Fejes, Zsolt, Szanto, Tibor Gabor, Fenyvesi, Ferenc, Váradi, Judit, Clarke, Luka A., Panyi, Gyorgy, Macek, Milan, Amaral, Margarida D., Balogh, István, Nagy, Béla
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8160512/ https://www.ncbi.nlm.nih.gov/pubmed/34054511 http://dx.doi.org/10.3389/fphar.2021.592184

Ejemplares similares

Endothelial cell activation is attenuated by everolimus via transcriptional and post-transcriptional regulatory mechanisms after drug-eluting coronary stenting
por: Fejes, Zsolt, et al.
Publicado: (2018)

Investigation of the Cellular Effects of Beta- Cyclodextrin Derivatives on Caco-2 Intestinal Epithelial Cells
por: Rusznyák, Ágnes, et al.
Publicado: (2021)

Preterm Intraventricular Hemorrhage-Induced Inflammatory Response in Human Choroid Plexus Epithelial Cells
por: Fejes, Zsolt, et al.
Publicado: (2021)

Cellular Effects of Cyclodextrins: Studies on HeLa Cells
por: Rusznyák, Ágnes, et al.
Publicado: (2022)

Human Epididymis Protein-4 (HE-4): A Novel Cross-Class Protease Inhibitor
por: Chhikara, Nirmal, et al.
Publicado: (2012)

Reduced miR-26b Expression in Megakaryocytes and Platelets Contributes to Elevated Level of Platelet Activation Status in Sepsis
por: Szilágyi, Bernadett, et al.
Publicado: (2020)

The epigenetic state of IL-4-polarized macrophages enables inflammatory cistromic expansion and extended synergistic response to TLR ligands
por: Czimmerer, Zsolt, et al.
Publicado: (2022)

Determination of reference intervals of serum levels of human epididymis protein 4 (HE4) in Chinese women
por: Tian, Yaping, et al.
Publicado: (2015)

Overexpression of HE4 (human epididymis protein 4) enhances proliferation, invasion and metastasis of ovarian cancer
por: Zhu, Liancheng, et al.
Publicado: (2015)

Diagnostic Performance of Serum Human Epididymis Protein 4 (HE4) for Prediction of Malignancy in Ovarian Masses
por: Dewan, Rupali, et al.
Publicado: (2019)

Functional Voltage-Gated Sodium Channels Are Present in the Human B Cell Membrane
por: Feher, Adam, et al.
Publicado: (2022)

Platelet Microparticles Enriched in miR-223 Reduce ICAM-1-Dependent Vascular Inflammation in Septic Conditions
por: Szilágyi, Bernadett, et al.
Publicado: (2021)

Role of Human Epididymis Protein 4 (HE4) in Determining Survival of Patients With Endometrial Cancer: A Meta-Analysis
por: He, Ying, et al.
Publicado: (2020)

Serum Human Epididymis Protein-4 (HE4) - A novel Approach to Differentiate Malignant from benign Breast Tumors
por: Baba, K S S Sai, et al.
Publicado: (2021)

Preparation and Testing of a Palladium-Decorated Nitrogen-Doped Carbon Foam Catalyst for the Hydrogenation of Benzophenone
por: Prekob, Ádám, et al.
Publicado: (2023)

Fluorescently Labeled Methyl-Beta-Cyclodextrin Enters Intestinal Epithelial Caco-2 Cells by Fluid-Phase Endocytosis
por: Fenyvesi, Ferenc, et al.
Publicado: (2014)

Human Epididymis Secretory Protein 4 (HE4) Compromises Cytotoxic Mononuclear Cells via Inducing Dual Specificity Phosphatase 6
por: James, Nicole E., et al.
Publicado: (2019)

An atlas of human proximal epididymis reveals cell-specific functions and distinct roles for CFTR
por: Leir, Shih-Hsing, et al.
Publicado: (2020)

Closed-state inactivation involving an internal gate in Kv4.1 channels modulates pore blockade by intracellular quaternary ammonium ions
por: Fineberg, Jeffrey D., et al.
Publicado: (2016)

Human epididymis protein 4 (HE4) is a novel biomarker for fibrosis in IgG4-related disease and can predict poor prognosis
por: Yan, Songxin, et al.
Publicado: (2022)

The Role of Hemoglobin Oxidation Products in Triggering Inflammatory Response Upon Intraventricular Hemorrhage in Premature Infants
por: Erdei, Judit, et al.
Publicado: (2020)

KLF4 Acts as a wt-CFTR Suppressor through an AKT-Mediated Pathway
por: Sousa, Luis, et al.
Publicado: (2020)

Human Epididymis Protein 4 (HE4) Reference Limits in Polish Population of Healthy Women, Pregnant Women, and Women with Benign Ovarian Tumors
por: Gasiorowska, Emilia, et al.
Publicado: (2019)

The Diagnostic Accuracy of Serum and Urine Human Epididymis Protein 4 (HE4) in Ovarian Cancer in 15,394 Subjects: An Updated Meta-Analysis
por: Nalini, Neelam, et al.
Publicado: (2022)

Association of CFTR gene mutation with bronchial asthma
por: Maurya, Nutan, et al.
Publicado: (2012)

Antimicrobial actions of the human epididymis 2 (HE2) protein isoforms, HE2alpha, HE2beta1 and HE2beta2
por: Yenugu, Suresh, et al.
Publicado: (2004)

Molecular rearrangements in S6 during slow inactivation in Shaker-IR potassium channels
por: Szanto, Tibor G., et al.
Publicado: (2023)

Effects of the Calix[4]arene Derivative Compound OTX008 on High Glucose-Stimulated ARPE-19 Cells: Focus on Galectin-1/TGF-β/EMT Pathway
por: Trotta, Maria Consiglia, et al.
Publicado: (2022)

Role of sepsis modulated circulating microRNAs
por: Szilágyi, Bernadett, et al.
Publicado: (2019)

Effectiveness of Anthocyanin-Rich Sour Cherry Extract on Gliadin-Induced Caco-2 Barrier Damage
por: Klusóczki, Ágnes, et al.
Publicado: (2023)

The activation gate controls steady-state inactivation and recovery from inactivation in Shaker
por: Szanto, Tibor G., et al.
Publicado: (2020)

Periodic Membrane Potential and Ca(2+) Oscillations in T Cells Forming an Immune Synapse
por: Papp, Ferenc, et al.
Publicado: (2020)

Efficacy of Pre- and Post-Treatment by Topical Formulations Containing Dissolved and Suspended Silybum marianum against UVB-Induced Oxidative Stress in Guinea Pig and on HaCaT Keratinocytes
por: Fehér, Pálma, et al.
Publicado: (2016)

The Proteasome Inhibitor Bortezomib Induces Apoptosis and Activation in Gel-Filtered Human Platelets
por: Ghansah, Harriet, et al.
Publicado: (2021)

Concentration-Dependent Antibacterial Activity of Chitosan on Lactobacillus plantarum
por: Kovács, Renátó, et al.
Publicado: (2022)

Clinical Usefulness of Human Epididymis Protein 4 in Lung Cancer
por: Choi, Soo In, et al.
Publicado: (2017)

Human Epididymis Protein 4 Levels in Neonates with Respiratory Disorder
por: Surmiak, Piotr, et al.
Publicado: (2020)

Association Between Micronutrient Concentrations and Human Epididymis Protein 4
por: Lim, Zhu Wei, et al.
Publicado: (2021)

Evaluation of human epididymis protein 4 (HE4) and Risk of Ovarian Malignancy Algorithm (ROMA) as diagnostic tools of type I and type II epithelial ovarian cancer in Japanese women
por: Fujiwara, Hiroyuki, et al.
Publicado: (2014)

Experimental and Theoretical Study of Cyclic Amine Catalysed Urethane Formation
por: Waleed, Hadeer Q., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_5bnmqtudr7fbetqdg2v28c4ut3