Cargando…

Global Genomic Analysis of SARS-CoV-2 RNA Dependent RNA Polymerase Evolution and Antiviral Drug Resistance

A variety of antiviral treatments for COVID-19 have been investigated, involving many repurposed drugs. Currently, the SARS-CoV-2 RNA-dependent RNA polymerase (RdRp, encoded by nsp12-nsp7-nsp8) has been targeted by numerous inhibitors, e.g., remdesivir, the only provisionally approved treatment to-d...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mari, Alfredo, Roloff, Tim, Stange, Madlen, Søgaard, Kirstine K., Asllanaj, Erblin, Tauriello, Gerardo, Alexander, Leila Tamara, Schweitzer, Michael, Leuzinger, Karoline, Gensch, Alexander, Martinez, Aurélien E., Bielicki, Julia, Pargger, Hans, Siegemund, Martin, Nickel, Christian H., Bingisser, Roland, Osthoff, Michael, Bassetti, Stefano, Sendi, Parham, Battegay, Manuel, Marzolini, Catia, Seth-Smith, Helena M. B., Schwede, Torsten, Hirsch, Hans H., Egli, Adrian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8160703/ https://www.ncbi.nlm.nih.gov/pubmed/34069681 http://dx.doi.org/10.3390/microorganisms9051094

Ejemplares similares

SARS-CoV-2 outbreak in a tri-national urban area is dominated by a B.1 lineage variant linked to a mass gathering event
por: Stange, Madlen, et al.
Publicado: (2021)

Community-acquired and hospital-acquired respiratory tract infection and bloodstream infection in patients hospitalized with COVID-19 pneumonia
por: Søgaard, Kirstine K., et al.
Publicado: (2021)

Comparing Immunoassays for SARS-CoV-2 Antibody Detection in Patients with and without Laboratory-Confirmed SARS-CoV-2 Infection
por: Leuzinger, Karoline, et al.
Publicado: (2021)

Determinants of SARS-CoV-2 transmission to guide vaccination strategy in an urban area
por: Brüningk, Sarah C, et al.
Publicado: (2022)

Effect of Systemic Inflammatory Response to SARS-CoV-2 on Lopinavir and Hydroxychloroquine Plasma Concentrations
por: Marzolini, Catia, et al.
Publicado: (2020)

Sex Differences in Lopinavir Concentrations and Occurrence of Marked QTc Prolongation Episodes in Patients with COVID-19
por: Marzolini, Catia, et al.
Publicado: (2020)

Empirical use of antibiotics and adjustment of empirical antibiotic therapies in a university hospital: a prospective observational study
por: Mettler, Julian, et al.
Publicado: (2007)

COVID-19 Triage and Test Center: Safety, Feasibility, and Outcomes of Low-Threshold Testing
por: Mansella, Gregory, et al.
Publicado: (2020)

Factors impacting the pre-analytical quality of blood cultures—Analysis at a tertiary medical center
por: Romann, Lucas, et al.
Publicado: (2023)

Identification of microorganisms by a rapid PCR panel from positive blood cultures leads to faster optimal antimicrobial therapy – a before-after study
por: Agnetti, Jessica, et al.
Publicado: (2023)

Systematic screening on admission for SARS-CoV-2 to detect asymptomatic infections
por: Stadler, Rahel N., et al.
Publicado: (2021)

Probability of pharmacological target attainment with flucloxacillin in Staphylococcus aureus bloodstream infection: a prospective cohort study of unbound plasma and individual MICs
por: Moser, Stephan, et al.
Publicado: (2021)

Complement and endothelial cell activation in COVID-19 patients compared to controls with suspected SARS-CoV-2 infection: A prospective cohort study
por: Bruni, Flavio, et al.
Publicado: (2022)

Targeting thromboinflammation in COVID-19 – A narrative review of the potential of C1 inhibitor to prevent disease progression
por: Urwyler, Pascal, et al.
Publicado: (2022)

Challenges of Primary Care Medicine in a Tertiary Care Setting—The Case of Primary CMV Infection Compared to Primary EBV Infection: A Retrospective Cohort Study
por: Etienne, Samuel, et al.
Publicado: (2022)

SARS-CoV-2 Vaccine Alpha and Delta Variant Breakthrough Infections Are Rare and Mild but Can Happen Relatively Early after Vaccination
por: Peter, Jelissa Katharina, et al.
Publicado: (2022)

Relative bradycardia in patients with COVID-19
por: Capoferri, Gioele, et al.
Publicado: (2021)

Impact of SARS-CoV-2 Omicron on Rapid Antigen Testing Developed for Early-Pandemic SARS-CoV-2 Variants
por: Leuzinger, Karoline, et al.
Publicado: (2022)

Treatment of COVID-19 With Conestat Alfa, a Regulator of the Complement, Contact Activation and Kallikrein-Kinin System
por: Urwyler, Pascal, et al.
Publicado: (2020)

Lactic acidosis and hyperlactatemia associated with lamivudine accumulation and sepsis in a kidney transplant recipient—a case report and review of the literature
por: Hollinger, Alexa, et al.
Publicado: (2021)

Cefiderocol for Extensively Drug-Resistant Gram-Negative Bacterial Infections: Real-world Experience From a Case Series and Review of the Literature
por: Zingg, Sandra, et al.
Publicado: (2020)

Nosocomial human parainfluenza virus type 3 outbreak in immunocompromised patients, and possible lessons from the SARS-CoV-2 pandemic
por: Gürtler, N., et al.
Publicado: (2022)

Succinylcholine versus rocuronium for rapid sequence intubation in intensive care: a prospective, randomized controlled trial
por: Marsch, Stephan C, et al.
Publicado: (2011)

Prosthetic valve endocarditis caused by Pseudomonas aeruginosa with variable antibacterial resistance profiles: a diagnostic challenge
por: Gürtler, Nicolas, et al.
Publicado: (2019)

Increasing prevalence of infectious diseases in asylum seekers at a tertiary care hospital in Switzerland
por: Bloch-Infanger, Constantine, et al.
Publicado: (2017)

Physiologically‐Based Pharmacokinetic Modeling to Support the Clinical Management of Drug–Drug Interactions With Bictegravir
por: Stader, Felix, et al.
Publicado: (2021)

ProMod3—A versatile homology modelling toolbox
por: Studer, Gabriel, et al.
Publicado: (2021)

Continuous Automated Model EvaluatiOn (CAMEO)—Perspectives on the future of fully automated evaluation of structure prediction methods
por: Robin, Xavier, et al.
Publicado: (2021)

Functional Activity of the Complement System in Hospitalized COVID-19 Patients: A Prospective Cohort Study
por: Charitos, Panteleimon, et al.
Publicado: (2021)

Low Levels of Mannan-Binding Lectin or Ficolins Are Not Associated with an Increased Risk of Cytomegalovirus Disease in HIV-Infected Patients
por: Egli, Adrian, et al.
Publicado: (2013)

Sleep-Wake and Circadian Disorders after Tick-Borne Encephalitis
por: Chiffi, Gabriele, et al.
Publicado: (2022)

A systematic outbreak investigation of SARS-CoV-2 transmission clusters in a tertiary academic care center
por: von Rotz, Matthias, et al.
Publicado: (2023)

Comparison of Whole Blood RNA Preservation Tubes and Novel Generation RNA Extraction Kits for Analysis of mRNA and MiRNA Profiles
por: Häntzsch, Madlen, et al.
Publicado: (2014)

Cerebral perfusion in sepsis-associated delirium
por: Pfister, David, et al.
Publicado: (2008)

Clinical utility of inflammatory biomarkers in COVID-19 in direct comparison to other respiratory infections—A prospective cohort study
por: Lampart, Maurin, et al.
Publicado: (2022)

Brief validation of the novel GeneXpert Xpress SARS-CoV-2 PCR assay
por: Goldenberger, Daniel, et al.
Publicado: (2020)

Precision Medicine in the Diagnosis and Management of Orthopedic Biofilm Infections
por: Baldan, Rossella, et al.
Publicado: (2020)

Lysins – a new armamentarium for the treatment of bone and joint infections?
por: Sendi, Parham, et al.
Publicado: (2022)

Bilateral acute renal cortical necrosis after a dog bite: case report
por: Amacher, Simon A., et al.
Publicado: (2021)

Adverse Events of Percutaneous Microaxial Left Ventricular Assist Devices—A Retrospective, Single-Centre Cohort Study
por: Zaiser, Anna S., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_i77a7svsk4u14l31djrvrlj438