Design, Synthesis, and Antitumor Activity of Olmutinib Derivatives Containing Acrylamide Moiety

Two series of olmutinib derivatives containing an acrylamide moiety were designed and synthesized, and their IC(50) values against cancer cell lines (A549, H1975, NCI-H460, LO2, and MCF-7) were evaluated. Most of the compounds exhibited moderate cytotoxic activity against the five cancer cell lines....

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Detalles Bibliográficos
Autores principales: Hu, Xiaohan, Tang, Sheng, Yang, Feiyi, Zheng, Pengwu, Xu, Shan, Pan, Qingshan, Zhu, Wufu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8160875/
https://www.ncbi.nlm.nih.gov/pubmed/34065165
http://dx.doi.org/10.3390/molecules26103041

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8160875/
https://www.ncbi.nlm.nih.gov/pubmed/34065165
http://dx.doi.org/10.3390/molecules26103041

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