A 3D Renal Proximal Tubule on Chip Model Phenocopies Lowe Syndrome and Dent II Disease Tubulopathy

Lowe syndrome and Dent II disease are X-linked monogenetic diseases characterised by a renal reabsorption defect in the proximal tubules and caused by mutations in the OCRL gene, which codes for an inositol-5-phosphatase. The life expectancy of patients suffering from Lowe syndrome is largely reduce...

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Detalles Bibliográficos
Autores principales: Naik, Sindhu, Wood, Andrew R., Ongenaert, Maté, Saidiyan, Paniz, Elstak, Edo D., Lanz, Henriëtte L., Stallen, Jan, Janssen, Richard, Smythe, Elizabeth, Erdmann, Kai S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161077/
https://www.ncbi.nlm.nih.gov/pubmed/34069732
http://dx.doi.org/10.3390/ijms22105361

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161077/
https://www.ncbi.nlm.nih.gov/pubmed/34069732
http://dx.doi.org/10.3390/ijms22105361

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